Turning The Metabolic Tide
Today I wanted to jump into a recently approved GLP-1 and GIP agonist that was very recently approved by the FDA in May of 2022.
Tirzepatide has also been fast tracked by the FDA for obesity for overweight adults with weight related comorbidities. As of now there are only 6 drugs approved for weight loss, so it should be understood that it is a highly effective compound.
Tinseltown & Tirzepatide?
Tirzepatide is yet another wonder drug in the world of a new class of drugs called GLP-1 agonists. If you have not read the previous article on semaglutide, which you can find here, I will break these down quickly. Glucagon-like Peptide 1 or GLP-1 receptor agonists are drugs that were initially designed for people with Type 2 Diabetes. GLP-1 being a major incretin hormone, incretins being hormones that help to stimulate insulin secretion and improve blood glucose levels. Semaglutide works by improving how well these increments work. GLP-1 receptors are also found all throughout the body which means that GLP-1 receptor agonists exert more effects than just mediating blood glucose levels, for example their impact on reducing appetite comes from GLP-1 receptors in the brain. One of the reasons these drugs are so popular is because of their profound ability to promote weight loss. Already two have been approved for weight loss by the FDA with the one this article is about Tirzepatide being fast tracked for it currently. It is to the point where Hollywood celebrities, even reportedly the Kardashians are using these drugs to help them lose massive amounts of weight. Of course, having a lower appetite helps with weight loss, but by keeping blood glucose levels in check these drugs help promote weight loss through an additional pathway. To simplify this when we have lower blood glucose levels, we put ourselves in a more optimal state for fat burning and can oftentimes partition nutrients better. When I say partition, I mean that the food we do eat and consume will go to places we want it to go to like the muscle instead of just becoming fat.
Tirzepatide: Outstanding in the Weight class
Now that we have established the basics of GLP-1 agonists let's get more into Tirzepatide specifically. Tirzepatide is not only a GLP-1 agonist, but it is also a GIP agonist. It was like other GLP-1 agonists designed for type 2 diabetes, obesity, and nonalcoholic steatohepatitis. Tirzepatide provides a unique pharmacological profile, in that it has higher engagement for the GIP receptor than the GLP-1 receptor. GIP or Glucose dependent insulinotropic polypeptide, communicates nutrient intake from the gut to islets, which enables the optimal level of insulin secretion via the GIP receptor receptors on the Beta cells. GIP receptors also are expressed in alpha cells which helps to balance glucagon and insulin secretion to help maintain postprandial homeostasis. Now in terms of Tirzepatides agonism of the GLP-1 receptor it favors cAMP generation over B-arrestin recruitment. Now this biased agonism is a part of a highly confusing process, but the takeaway is that because it favors cAMP it makes it a more effective compound! This combined with its ability to agonize GIP makes it a highly effective drug. While this may sound like a lot of confusing jargon like I said, the important thing here is that we just cover how the drug works so we can understand how effective it is, and effective for what things specifically. This unique mechanism of action makes Tirzepatide a potent compound that has been shown to be more potent at doses of 10 and 15mg than 2mg of Semaglutide in regard to HbA1c values although more proper trials are needed.
Another component of drugs is how it is taken and how often it needs to be taken. It is a concept called Medication Adherence. Say a drug needs to be injected every single day vs taken as a pill once per week. Obviously taking a pill once per week is far easier and makes it much easier for a patient to adhere to it than having to inject something daily. For tirzepaptide it was shown in studies to be a weekly injection that is dosed anywhere from 2.5mg all the way up to 15mg. Not that I am saying you should use this dose at all, you should only use what your doctor recommends, but these are what the studies show.
Now Tirzepaptide is a drug approved for human usage, but standard side effects may include abdominal pain, dyspepsia, nausea, vomiting, and thyroid C-cell tumors. Most people though do simply fine with the drug and have very few side effects. If you are concerned about the risk of thyroid cancer, it is important that you limit your usage of the drug to only when you are really trying too hard to lose weight instead of just using it year-round. Of course, though it is always advised upon to follow the set instructions given to you by your doctor. In the weight loss world, many other drugs like Clenbuterol are popular. To me this compound is equally effective and far safer than something like Clenbuterol for losing weight. Not only is it safer, but it can also aid in improving blood glucose levels, essential for our health.
In conclusion Tirzepaptide is an amazing and highly effective compound for weight loss and overall health. Most users who use it get minimal side effects, strong appetite suppression, and improved blood glucose levels putting them in a highly optimal state for fat loss. The drug’s dual mechanism of action of agonizing GIP and GLP-1 makes it potentially one of the most effective GLP-1 agonists on the market and something that you should investigate and speak to your doctor about for your longevity and weight loss journeys.
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